Endocrine Disruptors

The conference dives right into the ongoing debate surrounding the challenging implementation of the ECHA/EFSA guidance for the identification of Endocrine Disruptors and provides participants with all the recent regulatory and scientific developments.

20.11. — 21.11.2024
Novotel Düsseldorf City West
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ÜbersichtProgrammReferent:innenVeranstaltungsortPreise & Leistungen

Übersicht

Early Bird Bookings10% discount valid until 2 October 2024 with discount code: ENDOCRINE10

The ECHA/EFSA guidance for the identification of Endocrine Disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009 requires a highly complex and challenging assessment for all active substances. With the proposed introduction of stricter regulation for EDs under the CLP and REACH Regulations, the challenge has recently been broadened. This conference will dive into the debate surrounding Endocrine Disruptors and covers all the relevant recent regulatory and scientific developments.

The Conference will be taking place in Dusseldorf/Germany on 20 and 21 November 2024.

You can also follow all the exciting contributions via our live stream!

Please find all information on the virtual participation here.

Highlights

Regulatory Developments

  • Update from the Commission
  • Endocrine Disruptors – Crosstalk between the different EU Regulations on plant protection products, Biocides and REACH
  • Industry view on REACH and CLP-related developments
  • Current developments regarding Plant Protection Products and CLP
  • NGO – view on current developments

Methods: Studies, NAMs, AOPs

  • Eleutheroembryo assays for testing of estrogenic, androgenic and steroidogenic (EAS) activities in fish
  • German BfR: Using AOPs to build a WoE analysis for ED assessment

Thyroid

  • German UBA on thyroid endpoints in fish and fish embryo tests
  • Update on human relevance of thyroid-liver axis effects
  • Case studies applying the ECETOC CLE Thyroid-NDT-TAS to support the identification and classification of substances

Who should attend this conference?

Professionals working in the fields of:

  • Toxicology and ecotoxicology
  • Research and development
  • Registration, regulatory affairs
  • Chemical risk assessment
  • Legal and general counselling

Sectors that should take part:

  • Chemical/biocide/agrochemical/pharmaceutical/cosmetic industries
  • Research institutes
  • Regulatory authorities
  • Environmental and health risk consultants
  • Testing laboratories and contract research organisations (CROs)
  • NGOs

Picture Credit: © Subbotina Anna/shutterstock.com, © chestra - Fotolia.com

 

Programm

Wednesday, 20 November 2024

Timings are in Central European Time CET.



Morning Session | 09:20 – 13:00 CET
09:00
On-site registration and opening of the virtual meeting room
09:20
Welcome address by the organisers and the Chairs

Lennart Weltje, BASF, Germany
Emily McVey, National Institute for Public Health and the Environment (RIVM), The Netherlands

The presentation slots include sufficient time for questions and answers.
Regulatory Developments
09:30
Update from the Commission: Endocrine disruptors-related activities

Jordane Wodli, European Commission, Belgium

10:05
Update from EFSA: toxicological and ecotoxicological ED assessments

Simone Rizzuto, European Food Safety Authority (EFSA), Italy (virtual presentation)

10:40
Endocrine Disruptors – Crosstalk between the different EU Regulations: Regulatory differences between legislation on plant protection products, biocides and REACH

Chiara Marelli/Libero Mazzucchelli, Team Mastery, Italy

11:25
Coffee break
11:55
Current developments regarding REACH and CLP – a short overview

Helen Tinwell, Bayer CropScience, France

12:20
Industry view on current developments – EDs in REACH and CLP – a short overview

Stuard Hindle, Dow Europe, Switzerland

12:45
Discussion
13:00
Lunch break


Afternoon Session 14:00 – 17:40 CET
14:00
Member state view on endocrine disruptors in the REACH, plant protection and CLP regulation

Alan Breen, Department of Agriculture, Food and the Marine, Ireland

14:35
Vulnerability assessments in the ED context with focus on human health
  • Comparison of screening exercises for substances under different regulations
  • Chances and challenges of vulnerability assessments
  • Conclusions on ED and CLP

Nadia Wenske, Knoell, Germany

15:10
Coffee break
15:40
NGO – view on current developments
  • CLP hazard classes and ED guidance
  • Interface EDs in CLP and REACH
  • Discussing ED hazard classes as part of GHS

Ninja Reineke, CHEM Trust, Germany

Methods: Studies, NAMs, AOPs
16:15
Eleutheroembryo assays for testing of estrogenic, androgenic and steroidogenic (EAS) activities in fish
  • Introduction to ED fish embryo assays
  • Eleutheroembryos as “non-animal models”
  • Implementation into assessment strategy of the ECHA/EFSA ED guidance

Carsten Lange, BASF, Germany

16:50
Thresholds of adversity for endocrine disrupting substances: a conceptual case study

Judy Choi, German Federal Institute for Risk Assessment (BfR), Germany

17:25
Final discussion
17:40
End of the first day
18:30
Evening event

After the first conference day you are most welcome to attend our evening event for an unhurried evening of good food and leisure time. Please, join us to continue the day’s interesting discussions in a relaxed and comfortable atmosphere.



Thursday, 21 November 2024

Timings are in Central European Time CET.



Morning Session | 09:30 – 13:30 CET
09:30
Brief address by the Chairs

Lennart Weltje, BASF, Germany
Emily McVey, National Institute for Public Health and the Environment (RIVM), The Netherlands

Methods: Studies, NAMs, AOPs
09:40
Using AOPs to build a WoE analysis for ED assessment

Philipp Marx-Stölting, German Federal Institute for Risk Assessment (BfR), Germany

Thyroid
10:15
Update on thyroidal endpoints in fish and amphibian tests
  • Endpoints according to ECHA/EFSA guidance
  • New biomarkers/NAMs
  • Potential refinement of the amphibian metamorphosis assay

Andrea Ziková-Kloas, German Environment Agency (UBA), Germany

10:50
Update on the human relevance of thyroid-liver axis effects seen in rats – challenges and evidential considerations
  • Species differences and similarities
  • Indications from regulatory guidance and the available tools
  • Assessment of human relevance and interpretation in the regulatory framework

Lauren Kent, Corteva Agriscience, United Kingdom

11:25
Coffee break
11:55
Thyroid hormone modelling and PBPK using a pregnancy and a lactation model

Pavel Balazki, esQLABS, Germany

12:30
Case studies applying the ECETOC CLE Thyroid-NDT-TAS to support the identification and classification of substances that meet the endocrine disruptor criteria for the thyroid modality
  • ECETOC/CLE Thyroid Function – Neurodevelopmental – Testing and Assessment Scheme (Thyroid-NDT-TAS)
  • Correlation between thyroid hormone effects in offspring animals and neurodevelopmental toxicity and thresholds (ECETOC Thyroid Task Force)
  • Criteria to differentiate between CLP Criteria ED HH Cat 1 and ED HH Cat 2
  • Adverse Outcome Pathway and species difference investigations

Stephanie Melching-Kollmuss, Crop Life Europe (CLE) / BASF, Germany

13:05
Summary and final discussion
13:30
Lunch and end of the Conference

Referent:innen

 

Name

Unternehmen

Balazki

Pavel Balazki

esQLABS, Germany

Pavel Balazki is an expert on Software development for the Open Systems Pharmacology; R packages, Apps, and environments for Life Science R&D; PBP/TK and QSP/T modelling and simulation. He is currently Senior Consultant and Lead for SW ToolChain at ESQlabs. His educational background is in molecular bioinformatics and mathematical modelling.

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Breen

Alan Breen

Department of Agriculture, Food and the Marine, Ireland

Alan Breen is a Regulatory Toxicologist working with the Department of Agriculture, Food and the Marine of Ireland. He has 25 years of experience in the area of chemical safety evaluation and risk assessment and is also a member of the ECHA ED Expert Group.

mehrweniger

Judy Choi

German Federal Institute for Risk Assessment (BfR), Germany

Judy Choi is a Certified Toxicologist (DABT, ERT), currently working as a Senior Scientific Officer in the \"Toxicology of Active Substances and their Metabolites\" Unit, Department of Pesticides Safety, at the Federal Institute for Risk Assessment (BfR) in Berlin, Germany. One of her activities at BfR is the toxicological evaluation of active substances for ED potential of human health relevance, and she has been an invited expert in multiple meetings on ED with EFSA or ECHA.

mehrweniger

Stuart Hindle

Dow Europe, Switzerland

Steward Hindle is Associate Toxicology Manager at Dow in Switzerland with over 20 years of experience in toxicology and pharmacology. He previously worked as Programme Manager and Toxicologist at Philogen is a Swiss-Italian biotechnology company as well as occupying a position as Senior Researcher at Molteni Therapeutics in Italy.

mehrweniger
Kent

Lauren Kent

Corteva Agriscience, United Kingdom

Lauren Kent is a Global Regulatory Toxicologist at Corteva Agriscience, based in the UK. She has been a toxicologist for ~15 years, working across different sectors in government and industry. She holds both a Masters in Toxicology and a PhD in molecular pharmacology.

mehrweniger
Lange

Carsten Lange

BASF, Germany

Carsten Lange is working as an Ecotoxicologist at BASF Agricultural Solutions in Germany, conducting risk assessments for plant protection products. He is a pharmaceutical biotechnologist and toxicologist by training, holds a PhD in pharmaceutical and medicinal chemistry and has worked in pharmaceutical and medicinal research before. One of the current focuses of his work are New Approach Methodologies (NAMs) in Ecotoxicology, including ED embryo assays.

mehrweniger
Marelli

Chiara Marelli

TEAM mastery, Italy

Chiara Marelli (PhD) is the Head of the REACH Division in TEAM mastery. She graduated in chemistry in 2004 and she gained a PhD in organic chemistry at the University of Insubria (Italy) in 2008. After her education, Chiara worked in research and development in the chemical industry for several years. Chiara joined TEAM mastery in 2017, she has since gained in-depth expertise in REACH registration and authorisation processes. Besides her activities in the REACH Division, Chiara collaborates as toxicologist with the PHARMA Division of TEAM mastery.

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Marx-Stölting

Philip Marx-Stölting

German Federal Institute for Risk Assessment (BfR), Germany

Philip Marx-Stölting completed a paramedic education and holds a PhD in biochemistry/toxicology. He is currently employed at the German Federal Institute for Risk Assessment (BfR), where he is head of the project group ‘Testing and assessment strategies pesticides’ and head of the BfR working group on endocrine disruptors. He is a specialist in toxicology (Fachtoxikologe, DGPT) and an Eurotox registered toxicologist (ERT).

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Mazzucchelli

Libero Andrea Mazzucchelli

TEAM mastery, Italy

Libero Andrea Mazzucchelli (PhD) has been a Regulatory Scientist at TEAM mastery since 2020. He graduated in Environmental Sciences at the University of Insubria (Italy) in 2020 with a focus on occupational and environmental hygiene. In TEAM mastery Libero works in the Biocide Division dealing mainly with regulatory aspects and technical evaluations.

mehrweniger
McVey

Emily McVey

National Institute for Public Health and the Environment (RIVM), The Netherlands

Emily McVey is an experienced Regulatory Toxicologist and works at the Dutch National Institute for Public Health and the Environment – RIVM. Her specialties include environmental toxicology, wild vertebrates (birds, mammals, amphibians, fish), molecular mechanisms of toxicity, neurodevelopmental toxicity and endocrine disruption testing and assessment.

mehrweniger
Melching-Kollmuss

Stephanie Melching-Kollmuss

Crop Life Europe/BASF, Germany

Stephanie Melching-Kollmuss has been working in the field of regulatory toxicology for chemicals and plant protection products for over 20 years, for more than 15 years at BASF SE. Her special interest is in mixture toxicity and endocrine disruption. Stephanie was involved in two Cefic LRI projects: “Combined low-dose exposures to anti-androgenic substances” and “Developing a quantitative AOP for liver-mediated thyroid modulation after prenatal exposure to a xenobiotic compound in the rat”.

mehrweniger
Reineke

Ninja Reineke

CHEM Trust Europe, Germany

Ninja Reineke holds a PhD in chemistry and works with CHEM Trust as Head of Science, with the main focus on improving EU regulation on endocrine disruptors, e.g. within REACH and the pesticides law. Previously she worked for WWF on EU chemicals policy in Germany and in Brussels.

mehrweniger

Simone Rizzuto

European Food Safety Authority (EFSA), Italy

Simone Rizzuto is a Scientific Officer in the Pesticides Unit at the European Food Safety Authority (EFSA). He gained his PhD from Lancaster University and has collected a broad experience in several biology and ecotoxicology-related scientific positions over the past years.

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Tinwell

Helen Tinwell

Bayer CropScience, France

Helen Tinwell is a Distinguished Bayer Science Fellow and Regulatory Toxicology Group Leader. She has a PhD in genotoxicity and joined Bayer Crop Science in 2005 after having spent 17 years at Syngenta. Until recently, she has worked in research toxicology focusing on method development and mode of action investigations to address endocrine disruption. In 2017 she became team leader of the Regulatory Toxicology group. She leads the development and application of testing strategies for evaluating potential endocrine-disrupting properties of plant protection molecules in mammals and is a member of the ECPA ED Expert Group.

mehrweniger
Weltje

Lennart Weltje

BASF, Germany

Lennart Weltje holds a PhD in ecotoxicology and environmental chemistry and currently works as a Senior Ecotoxicologist at BASF conducting risk assessments for PPPs and biocides. He is also an honorary Professor at the Faculty of Agricultural Sciences of the Georg-August University in Goettingen. His former stations include the Dutch National Institute for Public Health and the Environment (RIVM).

mehrweniger

Nadia Wenske

knoell, Germany

Nadia Wenske (M.Sc.) is a Regulatory Toxicologist at knoell Germany. She studied biology at Ulm University, Germany and successfully finished the toxicology master’s programme at Karolinska Institutet in Stockholm, Sweden. Her thesis, conducted in the chemical industry, focused on the identification of endocrine disruptors for industrial chemicals under REACH. After graduating, Nadia joined knoell in 2021 and has since then worked in various regulatory areas (biocides, REACH, plant protection products) with a focus on human health and endocrine disruptor assessments. She has gathered extensive experience with the preparation of ED assessments within different regulatory contexts and is one of the key contacts for the topic endocrine disruptors at knoell.

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Jordane Wodli

European Commission, Belgium

Jordane Wodli currently serves as a policy advisor national expert on chemicals in the European Commission’s DG Environment.

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Ziková-Kloas

Andrea Ziková-Kloas

German Environment Agency (UBA), Germany

Andrea Ziková-Kloas joined German Environment Agency in 2023 as head of section ”Ecotoxicological Laboratory” after having spent 7 years at German Federal Institute for Risk Assessment. Her PhD and postdoc research focused on endocrine disruption (ED) using various in vitro methods and in vivo models, especially fishes and amphibians. She is also a visiting scientist at Leibniz-Institute of Freshwater Ecology and Inland Fisheries within the framework of ED research.

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